【Abstract】 Objective To compare the curative effect of differences frequency radial extracorporeal shock wave in post herpes zoster neuralgia. Methods 160 patients of lower limb femoral nerve neuralgia post herpes zoster were randomly divided into control group, 5Hz treatment group, 10Hz treatment group and 15Hz treatment group. All patients were routinely given pregabalin capsules during treatment period, and then, 5,10, and 15 Hz treatment groups were given 5 , 10, and 15 Hz decentralized extracorporeal shock waves (1 time/week for 4 times) , after make a comparison for pain degree, depression, and changes in the lower extremity femoral nerve conduction velocity (MNCV) before and after treatment, in addition documented adverse events. Result The comparison of pain intensity scores of treatment group was significantly lower than that before treatment(P<0.05). In addition, compared with the control group, the 5,10, and 15 Hz treatment groups were significantly lower (P<0.05). The anxiety symptom scores. The treatment group were significantly lower than them before treatment(P<0.05). In addition, compared with the control group, the 10 and 15 Hz groups were significantly lower (P<0.05). There was no significant difference of electromyography between the two groups before and after treatment(P>0.05). 5 cases of adverse reactions occurred in the 15 Hz group, 4 cases of local ecchymoses and 1 case of swelling, all recovered spontaneously. The rate was higher than that them in the control group, 5 and 10 Hz(P<0.05). Conclusion Extracorporeal shock wave treat post-herpetic neuralgia is effective, but there are certain differences in frequency among them. 10Hz is better, and it does not cause nerve damage and side effects.