【Abstract】 Objective To explore the correlation between the levels of serum immunoglobulin E(IgE) , tumor necrosis factor-«(TNF-«) and interferon-y(INF-y) and disease severity in children with asthma. Methods 118 children patients with asthma admitted to hospital from June 2017 to June 2018 were enrolled in asthma group. Another 48 healthy children who were recruited for physical examination inthehospital were used as normal control group. The serum levels of IgE, TNF-a and INF-y were detected in the two groups. The correlation between these serum factors levels and asthma severity was analyzed. Results The levels of serum IgE and TNF-a in asthma group were significantly higher than those in control group while the INF-y level was significantly lower than that in control group(P<0.05). There were significant differences in the serum levels oflgE, TNF-a and INF-y among asthma children patients with different airway obstruction and asthma severity. The levels of serum IgE and TNF-a were positively correlated with airway obstruction degree and asthma severity, and the level of INF-y wasnegatively correlated with airway obstruction degree and asthmaseverity. Conclusion The levels of serum IgE, TNF-a and INF-y in children may be involved in the occurrence and development of asthma, and they are significantly correlated with the airway obstruction degree and asthma severity. Clinical detection of IgE, TNF-a and INF-y levels can predict occurrence and severity ofasthma, and it contributes to the prevention and treatment of asthma.