【Abstract】 Objective To explore the correlation between bone metabolism and insulin resistance in obese children. Methods 553 children consented to be included in this study and received bone mineral density examinations during the physical examination of children's health clinics from December 2016 to December 2017 in Qingdao Municipal Hospital were collected. Subjects were divided into obese and normal groups according to BMI. Logistic regression was used for multivariate analysis of the differences between the obese and normal groups, and to screen for potential risk factors that may lead to obesity. Pearson correlation was used to analyze the correlation between bone mineral density and other research indicators. Results There were 164 children in obese group and 389 children in normal group. The proportion of males, BMI, serum phosphorus, ALP, PTH, fasting blood glucose, TG, LDL, and HOMEIR in the obesity group were higher than those in the normal group (P＜0.05), while serum calcium, serum osteocalcin, HDL, BGP were lower than the normal group (P＜0.05). BMI increased (OR=1.17), male (OR=1.21), TG increased (OR=232), HOMEIR index increased (OR=2.51), LDL increased (OR=1.92), BGP decreased (OR= 0.81) is a possible risk factor for childhood obesity. BMI (r=0.631), TG (r=0.524), and HOMEIR index (r=0.645) were negatively correlated with BGP (P＜0.05). Conclusion There is a negative correlation between BGP and insulin resistance in children. The HOMEIR index can guide the screening of target population for bone mineral density detection in children.