【Abstract】 Objective To investigate expression of bcl2 interacting mediator of cell death (BIM) and p53 upregulated modulator of apoptosis (PUMA), so as to explore the correlation between BIM and PUMA in clinicopathological features and prognosis of cervical cancer. Methods The clinical data of 124 patients with cervical cancer admitted in our hospital from April 2013 to April 2015 were retrospectively analyzed. 124 cases of cervical cancer tissues (study group) and normal tissues specimens of other benign cervix diseases (control group) were collected. The BIM and PUMA of all the tissues were examined, and their correlation with the clinicopathological features and prognosis were analyzed. Results The expression of BIM and PUMA in cervical cancer tissues of cervical cancer patients was lower than that in adjacent normal tissues specimens of other benign cervix diseases(P＜0.05). The expressions of BIM and PUMA were not significantly related to the age, tumor size, pathological type and myometrial invasion depth (P＞0.05). The expression of BIM was related to FIGO stage, lymph node metastasis, and differentiation (P＜005). The survival time of patients with FIGO stage II, lymph node metastasis, poorly differentiated, BIM, and negative PUMA protein was significantly shortened (P＜0.05). The multivariate Cox proportional hazards regression analysis showed that FIGO stage II, lymph node metastasis, poorly differentiated and BIM, and negative PUMA protein were independent risk factors affecting the prognosis of cervical cancer patients (P＜0.05). Conclusion The low expression of BIM and PUMA protein in cervical cancer tissues of cervical cancer patients is positively correlated with the FIGO stage II, lymph node metastasis, poorly differentiated, and those factors are the independent risk factors affecting the prognosis of cervical cancer patients.