【Abstract】 Objective To study the influence of health lifestyle intervention of children led by community medical staff on sexual precocity. Methods 6537 healthy children aged 08 years given child health care in 6 community health service centers in the three districts of Nanchong City were selected by cluster random sampling. They were randomly divided into experimental group (3270 cases) and control group (3267 cases). The experimental group was given child health knowledge guidance while conducting sexual precocity related knowledge and healthy lifestyle guidance. The control group was given routine child health knowledge guidance. The incidence of sexual precocity and the effect of intervention were observed within 4 years. Results The scores of precocious puberty knowledge and healthy lifestyle in the experimental group were higher than those in the control group (P＜0.01). The children in the two groups were compared before and after the intervention. The healthy lifestyle scores of the experimental group were significantly higher than those before the intervention (t=6986, P＜0.01). The parental precocious knowledge scores were significantly higher than those before intervention (t=5864, P＜0.01), and there were significant statistical differences (P＜0.01). There was no knowledge of healthy lifestyle and sexual precocity in the sexual precocity group. There was no significant difference between the groups before and after intervention (P＞0.05). The healthy lifestyle of the experimental group was better than that of the control group (P＜0.01). The detection rate of precocious children in the experimental group was lower than that in the control group, which was statistically significant (P＜0.01), and the incidence rate of girls was higher than that of boys. Conclusion Community doctors are leading the way, combining child care with sexual precocity intervention to prevent, intervene, control, develop a healthy lifestyle, reduce the incidence of central precocious puberty, and even prevent sexual precocity in children. Provide effective and effective ways to prevent and control sexual precocity.