【Abstract】 Objective To investigate the control effect of Danshen Chuanxiongqin injection on radiationinduced lung injury in patients with locally advanced nonsmall cell lung cancer (NSCLC). Methods Eighty patients with locally advanced NSCLC treated in the hospital from December 2016 to November 2017 were divided into the control group and the observation group by the random number table method, 40 cases in each group. Both groups were given radiotherapy, and on the basis, the observation group was additionally treated with Danshen Chuanxiongqin injection. Effects of radiotherapy, levels of plasma transforming growth factorβ1 (TGFβ1), serum intercellular adhesion molecule (ICAM1) and lung function indicators ［forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and carbon monoxide diffusion capacity (DLCO)］ were compared between the two groups. Imaging examinations were performed on both groups, and the incidence of adverse reactions was recorded. Results There was no significant difference between the effective remission rate between the two groups (5750% vs 5000%) (P＞0.05). Levels of plasma TGFβ1 and serum ICAM1 in the observation group after treatment were lower than those in the control group (P＜0.05), but there was no significant difference in FVC or FEV1 (P＞0.05). The DLCO level was higher than that in the control group (P＜0.05). The incidence rates of radiation pneumonitis and radiationinduced pulmonary fibrosis in the observation group (1250% and 1000%) were lower than those in the control group (3250% and 3250%) (P＜0.05). There was no significant differences in adverse reactions between the two groups (P＞0.05). Conclusion Danshen Chuanxiongqin injection can improve the lung diffusion function and reduce radiationinduced lung injury in patients with locally advanced NSCLC.