【Abstract】 Objective To investigate the longterm prognostic value of three different modes of treatment for patients with primary liver cancer (PLC). Methods 24 patients with PLC treated in our hospital from January 2008 to December 2014 were selected as the study subjects. The clinical and followup data of all patients were analyzed by retrospective analysis. They were divided into group A (46 cases), group B (52 cases) and group C (26 cases). All patients were treated with symptomatic treatment. Group A was treated with TACE intervention on this basis. Group B was treated with TACE. Group C was treated with TACE and 3DCRT. At the end of the treatment, the general clinical data including gender, age, disease status and related clinical indicators, recent clinical efficacy, and longterm prognosis of survival were recorded. Compare the differences of the above data among the three groups of patients and analyze the factors that influence the longterm prognosis of patients with primary liver cancer. Results There was no significant difference in clinical total effective rate among the three groups of PLC patients after treatment (P＞005). From the time of discharge from hospital to the end of followup, the median survival time of 124 patients with PCL was 268 months, and the prognosis survival rates of PLC patients in group B and C at different followup time points were significantly higher than those of PLC patients in group A. The 3year survival rate was also significantly increased (P＜005), but there was no difference in the prognosis survival rate of PLC patients between group B and C at different time points (P＞005). Single factor analysis by Logrank test showed that there were differences in survival time among PLC patients with different liver function classification, clinical stage, AFP level, treatment method, and with or without portal vein suppository, cirrhosis, and lymph node metastasis (P＜005). Multivariate stepwise Cox regression analysis showed that portal vein suppository, cirrhosis and lymph node metastasis, and TACE treatment alone were all independent risk factors affecting the prognosis of PLC patients (P＜005). Conclusion Compared with TACE alone, TACE combined surgery and TACE combined with 3DCRT treatment can further improve the longterm survival rate of PLC patients, and is more suitable for clinical PLC treatment.