【Abstract】 Objective To study curative efficacy of Fashudil joined edalavin in treatment of cerebral vasospasm after intracranial aneurysm ruptureand its effectson serum Soluble intercellular adhesion molecule1 (sicam1), Aspartic acid proteolytic enzyme 3 (caspase3). Methods 95 patients with subarachnoid hemorrhage admitted from May 2015 to March 2017 were selected and divided into the observation group (n=50) and the control group (n=45). The control group was treated with idaravone and the observation group was treated with fasudil on the basis of the control group. The incidence of postoperative vasospasm and delayed cerebral infarction, serum SICAM 1, Caspase 3 level, Glasgow Coma Scale (Glasgow Coma Scale, GCS), pap (Barthel index score, nerve function defect (NFI) score, middle cerebral artery (MCA) average blood flow velocity and adverse reactions occur were observed. Results The incidence of vasospasm and delayed cerebral infarction in the observation group was significantly lower than that in the control group (P＜ 005). Before treatment, there was no significant difference in serum sicam1, caspase3 levels between the two groups (P＞ 005). After treatment, serum sicam1, caspase3 levels of the two groups significantly decreased compared with those before treatment (P＜ 005), and serum sicam1, caspase3 levels of the observation group were significantly lower than those of the control group (P＜ 005). Before treatment, there was no significant difference in MCA mean blood flow velocity between the two groups (P＞ 005). After treatment, the average MCA blood flow velocity of both groups increased significantly compared with that before treatment (P＜ 005), and the average MCA blood flow velocity of the observation group was significantly higher than that of the control group (P＜ 005). Before treatment, there was no significant difference in GCS score, Barthel index score and NFI score between the two groups (P＞ 005). GCS score after treatment, two groups, the Barthel index score before treatment were significantly elevated, NFI score decreased significantly (P＜ 005), GCS score, Brthel index score and observation group were significantly higher than the control group, NFI score was significantly lower than control group (P＜ 005); The total incidence of adverse reactions in the observation group was 1200%, significantly lower than the control group's 3333% (P＜ 005). conclusion To use in patients with cerebral vasospasm after ruptured intracranial aneurysm shu to adr mentioned joint effect is remarkable, which can effectively improve the patient's serum SICAM 1, Caspase 3,level, is worth popularization and application.