【Abstract】 Objective To compare the effects of limited and active liquid resuscitation on coagulation function and prognosis in multiple traumas with moderate and severe craniocerebral injury. Methods 146 moderate and severe craniocerebral injury with multiple traumas treated in our hospital from Apr 2015 to Mar 2017 were analyzed and randomly divided into active group (n=73) and limited group (n=73), according to the random number table. The clinical data of the two groups were analyzed retrospectively. The fluid resuscitation, coagulation function indexes, base excess (BE) and lactic acid (LA) concentrations were observed and recorded. The progress of intracranial hemorrhage was also evaluated between the two groups. And the prognosis was assessed by Glasgow Outcome Scale (GOS). Results The average fluid intake in the active group was significantly higher than that in the limited group (P＜005). The colloid usage and early resuscitation time in the active group were higher than those in the limited group, with no significant difference between the two groups (P＞005). After treatment, serum APTT, TT, PT, and DD levels were significantly decreased (P＜005), which were lower in the limited group than in the active group (P＜005); After treatment, the BE and LA levels in the limited group were significantly lower than those in the active group (P＜005). After treatment, the proportion of intracranial hemorrhage progression and postoperative surgery in the active group was significantly higher than that in the limited group (P＜005). 1 week after admission, the GCS scores of the active group were significantly lower than those in the limited group (P＜005); The good prognosis rate in the limited group was significantly higher than that in the active group (3836% vs 6438%, P＜005). The incidence of complications (2055%) and mortality (1233%) in the active group were significantly higher than those in the restricted group (959% and 548%) (P＜005). Conclusion Compared with the active liquid resuscitation, the limited liquid resuscitation can effectively reduce the amount of resuscitation fluid, ameliorate the coagulation dysfunction, improve the organ perfusion and oxygen supply in shock stage, decrease the incidence rate of the intracranial rebleeding, and improve the prognosis of moderate and severe craniocerebral injury with multiple traumas.