【Abstract】 Objective To discuss the related risk factors of progressive ischemic stroke, focusing on explaining the clinical significance of monitoring thyroxine level in patients with progressive ischemic stroke. Methods 230 acute cerebral infarction patients distributed into progressive and nonprogressive group were allowed into the study. All patients were admitted to hospital between August 2016 and July 2017. Risk factors, imaging material and other clinical data associated with cerebrovascular disease were also collected. The major risk factors of progressive ischemic stroke were analyzed. Results In 47 cases of progressive ischemic stroke group, 37 cases had the history of hypertension, accounted for 787%. Meanwhile, 24 cases had infection(511%). In 183 cases of nonprogressive group, 114 cases had the history of hypertension which accounted for 623%, 27 cases had pulmonary infection(148%). There were significant differences between two groups(P＜005). Compared to the nonprogressive group, progressive group had a lower level of FT3 (t=4227, P＜0001) and higher FT4 level (t=7153, P＜0001).The multivariate logistic regression analysis results showed that coinfection and a higher level of FT4 were independent risk factors of progressive ischemic stroke（P＜005）.Conclusion Serum FT4 level in the group of progressive stroke is significantly higher than that of in the group of nonprogressive stroke. FT4 is an independent risk factor for progressive stroke. Early monitoring of thyroxine levels can help predict disease progression and prognosis. Concurrent infection is another independent risk factor of progressive stroke.