【Abstract】 Objective To study curative efficacy of ursodeoxycholic acid combined with blue light intermittent irradiation in treatment of neonatal jaundice and effects on serum total bile acid (TBA), transferring (TRF), total bilirubin (TBIL). Methods 160 patients of neonatal jaundice received therapy from March 2015 to March 2016 in General Hospital of china Aviation were selected as research objects. According to random number table, those patients were divided into the observation group (n=80) and the control group (n=80). On the basis of routine symptomatic treatment, they took oral the Ursodeoxycholic acid tablets. The observation group was given the blue light intermittent irradiation, each time 3~5h, stop 2~4h again. The control group was given the blue light continuous irradiation, each time 12~16h, stop 8~12h again, continuous treatment of 4d. The clinical efficacy, the changes of myocardial enzyme spectrum, serum TBA, TRF and TBIL before and after treatment, jaundice disappearance time and the incidence of adverse reaction were compared between the two groups. Results After treatment, the total effective efficiency of the two groups was 90% and 9250%, and there was no significant difference(P＞0.05). After treatment, the aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzyme (CKMB) of the two groups were significantly lower than before treatment(P＜0.05). There was no significant difference in AST, LDH, CK and CKMB after treatment between the two groups (P＞0.05). After treatment, the serum TBA and TBIL of the two groups were significantly lower than those before the treatment, and the TRF was significantly increased (P＜0.05). There was no significant difference in serum TBA, TRF and TBIL after treatment between the two groups (P＞0.05). There was no significant difference in the jaundice disappearance time between the two groups (P＞0.05). The total incidence of diarrhea, rash, dehydration, anorexia and fever in the observation group was 11.25%, which was significantly lower than that of the control group 3750%. The differences were statistically significant(P＜0.05). Conclusion The effect of ursodeoxycholic acid combined with blue light intermittent irradiation and blue light continuous irradiation were similar, which could effectively improve the expression of serum TBA, TRF and TBIL, promote the jaundice disappearance. However, combined with blue light intermittent irradiation has less adverse reaction and higher safety.