Objective To analyze the clinical characteristics and drug resistance of K. pneumoniae in ICU, and provide evidence for the rational use of antibiotics in clinical practice. Methods The K.pneumoniae infections in ICU from January 2014 to December 2016 were analyzed. Drug susceptibility test adopted disk diffusion method. Extended-spectrum β-lactamase was detected with doubledisc synergy test.Results K. pneumoniae infection in our hospital ICU was common in elderly patients with multiple predisposing factors. Respiratory tract was the main infection site. Patients with CREKp had a high mortality rate. Most of them were associated with septic shock or multiple organ failure. The resistance rate of the detected strains to the commonly used antibiotics increased to varying degrees. Particularly CREKp strains was gradually increasing and characterized by pan-drug resistance, only sensitive to tigecycline and minocycline.Conclusion The incidence of K. pneumoniae infection in ICU is high and the disease is serious. The mortality of CREKp infection is high. We should fully recognize its seriousness. It is especially important to guide the clinical selection of appropriate antibiotics based drug susceptibility testing results.