【Abstract】 Objective To investigate the effect of age and hemoglobin on the prognosis of patients with STsegment elevation acute myocardial infarction (STEMI) after reperfusion therapy. Methods 126 patients with STEMI treated with reperfusion in our hospital from January 2012 to January 2015 were enrolled. The clinical and followup data of all patients were analyzed retrospectively. According to the results of the data, the general clinical data such as gender, age, and disease history of all patients, the related clinical indicators such as disease situation and hemoglobin and prognostic effects after reperfusion therapy were recorded. The differences in the above data between patients with different prognostic effects were compared.Results In 126 patients with STEMI, 106 patients had a good prognosis after reperfusion treatment, accounting for 8413%, and the prognosis of 20 patients was poor, accounting for 1587%. In STEMI patients who was more than 60 years, the proportion of women and diabetes was low and the killip classification of cardiac function was low, while there were fewer smokers and alcoholics, and they had lower hemoglobin level and poorer prognostic effects (P＜005). The proportion of women, smoking and diabetes, age, and the killip classification of cardiac function in patients with moderate to severe anemia were significantly higher than that in patients with no anemia and mild anemia, and the difference in worse prognosis of the former two groups was statistically significant (P＜005). STEMI patients who had a history of diabetes, and habits of smoking, drinking, had exorbitant killip classification of cardiac function ,dyslipidemia and moderate to severe anemia,and was more than 60 years, had a poor prognosis after reperfusion (P＜005). The unconditional multivariate Lgistic regression model showed that the exorbitant killip classification, dyslipidemia ,age more than 60 years old and moderate to severe anemia were independent risk factors for the prognostic effects of STEMI after reperfusion (P＜005). Conclusion The prognostic effects of STEMI patients after reperfusion therapy is acceptable. However, age more than 60 years old and the presence of moderate to severe anemia are independent risk factors affecting the prognostic effects of STEMI after reperfusion therapy. They can be combined as an effective indicator for clinical evaluation of the prognostic effect in STEMI patients after reperfusion therapy.