【Abstract】 Objective To investigate the application of mobile phone WeChat software in the followup of patients with total knee arthroplasty (TKA).Methods 100 patients with primary TKA from January 2017 to October 2017 were randomly divided into WeChat followup group (experimental group) and telephone followup group (control group), with 50 patients in each. The frequency of followup was 1 week and lasted for 3 months. The Hospital for Special Surgery (ROM), Range of Motion (ROM), and SelfRating Anxiety Scale (SAS) were evaluated in the 1 week after surgery, and 1, 3 months after surgery. The patients' satisfaction, the time spent in followup and the incidence of complications were compared between the two groups.Results There was no significant difference in baseline data between the two groups before surgery (P＞005). At 1 week and 1, 3 months after surgery, the HSS score and ROM score of the experimental group were higher than those of the control group. The time spent in followup in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜005). Conclusion Based on the current evidence, the application of the WeChat software can significantly improve the patient's clinical outcomes and satisfaction.