【Abstract】 Objective To investigate the treatment effects of Haikun Shenxi capsule on renal function and pathological state in rats with chronic renal failure. Methods 35 rats were randomly divided into control group, model group and experimental group. Model group and experimental group were given adenine to establish CRF model. After successful modeling, the experimental group was intragastrically administered with Haikun Shenxi capsule solution (011g/100g·d), and control group and model group were given the same amount of normal saline. The renal functionrelated indexes of blood urea nitrogen (BUN) and creatinine (Scr) and inflammatory factors of tumor necrosis factorα (TNFα) and interleukin6 (IL6) were measured. The expression levels of fibronectin (FN), laminin (LN), αsmooth muscle actin (αSMA) and transforming growth factorβ (TGFβ) in renal tissues were measured. The renal tissue fibrosis was determined by Masson staining. Results Compared with control group, the contents of BUN, Scr, TNFα and IL6 in model group and experimental group were significantly increased (P＜005), and the protein expression levels of αSMA and TGFβ were significantly increased (P＜005). Compared with model group, the contents of BUN, Scr, TNFα and IL6 in experimental group were significantly decreased (P＜005), and the protein expression levels of αSMA and TGFβ were significantly reduced (P＜005). The renal tissue fibrosis in experimental group was significantly improved in Masson staining. In the immunohistochemistry experiment, the protein expression levels of FN and LN in experimental group were significantly reduced. Conclusion Haikun Shenxi capsule can treat the chronic renal failure in rats by inhibiting the process of renal tissue fibrosis and reducing the secretion of inflammatory factors.