【Abstract】 Objective To investigate the influence of PRC1 expression on the clinicopathologic characteristics and prognosis of patients with bladder cancer (BC).Methods The dataset GSE13507 was obtained from GEO database. Unpaired ttest was conducted to estimate the expression of PRC1in normal bladder tissue and BC cells. Chisquare test was carried out to analyze the relationships between the PRC1 expression levels and clinical features of patients who suffered from BC. Logrank based survival analysis was performed to the survivals in patients with BC. GSEAwas conductedtoexplorethe gene sets enrichedin PRC1highexpression samples.Results Compared with the levels in normal bladder tissues, PRC1 mRNA levels was increased in BCs. Patients in PRC1 high expression group were correlative with worse clinicopathological characteristics (including gender, age, progression, muscular infiltration, T stage, N stage, and tumor grade) compared with those in PRC1 low expression group. PRC1 high expression was associated with worse prognosis in terms of cancer specific survival and overall survival. The results of GSEA showed that PRC1 might affect the occurrence and development of BC by regulating spermatogenesis, G2M checkpoint and ,E2F signaling, unfoldedproteinrespond, mTORC1 signaling, MYC_TARGETS_V2, MYC_TARGETS_V1, P13KAKTmTOR signaling, mitotic spindle, cholesterol homeostasis and glycolysis. Conclusion PRC1 may make sense in prognosis and treatment of BC as potential marker and target.