【Abstract】 Colorectal cancer (CRC) is caused by multiple genomic accumulation and epigenetic changes that transform colonic epithelial cells into aggressive malignant adenomas. Epigenetics refers to the study of changes in gene expression levels, including DNA methylation, histone modification, chromatin remodeling, and RNA interference, when nucleotide sequences of genes are not altered. Among them, DNA methylation is the most important epigenetic modification, and it is also the most indepth field of study. Studies have found that epigenetic changes play an important role in the carcinogenesis of colorectal cancer, in these processes, some of the above list of epigenetic change typically have the function or loss of tumor suppressor gene function to cancer gene. This article reviews the recent advances in the study of DNA methylation in colorectal cancer.