【Abstract】 Plasma Adrenomedullin (ADM) is an endogenous peptide with a variety of biological activities including vasodilation, hypotension, expansion of bronchial smooth muscle cell, improving microcirculation, stabilizing the function of vascular endothelial, regulating pulmonary arterial pressure, regulating inflammation and immune function, participating in the secretion and regulating of multiple hormones. It takes action in an autocrine, paracrine and endocrine manner. It was named for its initial discovery in adrenal pheochromocytoma. Later it was found expressed in a variety of organs and tissues, including heart, brain, kidney, tumor tissue, especially in endothelial cells, vascular smooth muscle cells and also widespread in human lung tissue. At present, many studies have found that adrenomedullin may be involved in the pathophysiology of certain lung diseases, including community-acquired pneumonia, bronchial asthma, chronic obstructive pulmonary disease, pulmonary hypertension, lung cancer and other diseases. This article reviews the research progress of adrenomedullin in the related disease of respiratory system.