【Abstract】 Objective To study the diagnostic value of contrastenhanced ultrasound in the diagnosis of papillary thyroid carcinoma.Method The clinical data of 83 patients with papillary thyroid carcinoma who were treated in our hospital from January 2015 to February 2017 were reviewed. All subjects underwent routine ultrasound and ultrasonography. The patient's lesions were observed and recorded. The relationship between cancer nodules and thyroid capsule was analyzed. McNemar test was used to compare the diagnostic efficacy of both methods.Results Of 83 patients，there were 51 patients in infringement group and 32 patients in noninvasive group. The tumor size of infringement group and noninvasive group were 087 ± 049 cm and 127 ± 078 cm (t= 2265， P＜005).There were 29 cases of cervical lymph node metastasis (5686%). There were 17 cases of cervical lymph node metastasis in the noninvasive group (5313%). There was no significant difference between the two groups （X2= 1265， P= 0156）. Under normal ultrasound and ultrasound contrast examination, the accuracy, specificity, sensitivity and negative predictive value of conventional ultrasound were decreased with the increase of the contact area between the nodule and the thyroid capsule (P＜005). The area under the curve of group B was greater than that of group C（P＜005）. The area under the R0C curve was statistically significant (Z= 4321， P＜005). The area under the R0C curve was statistically significant (Z= 4321， P＜0050). The area under the R0C curve of the patients with thyroid papillary carcinoma was significantly higher than that in the control group (P＜005). Conclusion Ultrasonography under examination of thyroid papillary carcinoma capsule invasion than the conventional control group， with important clinical value.