【Abstract】 Objective To study curative efficacy of Jianwei Yuyang tablets combined with triple therapy in treatment of reflux esophagitis. Methods 90 patients of reflux esophagitis who received therapy from February 2015 to February 2017 in our hospital were selected. According to random number table, those patients were divided into the observation group (n=45) and the control group (n=45). On basic treatment, the control group was treated with triple therapy(Omeprazole + metronidazole + amoxicillin), while the observation group was combined with Jianwei Yuyang tablets, They were treated continuously for 4 weeks. The changes of serum levels of gastrin(GAS), Nitric oxide(NO), growth hormone releasing polypeptide(Ghrelin), Leptin and clinical symptom scores were compared between the two groups before and after treatment, and the mucosal healed rate and clinical efficacy were compared after treatment. Results After treatment, the levels of serum GAS and Ghrelin in the two groups were significantly higher than those before treatment, and levels of serum NO and Leptin decreased significantly(P＜005); and the levels of serum GAS and Ghrelin in the observation group were significantly higher than those in the control group, and the levels of serum NO and Leptin were significantly lower than those in the control group(P＜005); after treatment, the scores of heartburn, acid regurgitation, chest pain symptom in the two groups were significantly lower than those before treatment(P＜005), and the scores of heartburn, acid regurgitation, chest pain symptom in the observation group were significantly lower than those in the control group(P＜005); the total mucosal healed rate in the observation group were significantly lower than those in the control group(P＜005); the total effective rate of clinical efficacyin the observation group were significantly lower than those in the control group(P＜005). Conclusion Jianwei Yuyang tablets combined with triple therapy is well for reflux esophagitis, which can effectively promote the healing of esophageal mucosa, relieve the clinical symptoms and improve the clinical efficacy, it’s internal mechanism may be related to regulating the expression of serum GAS, NO, Ghrelin and Leptin.