【Abstract】 Objective To investigate the effect of longchain noncoding RNAH19 on the invasion and metastasis of cervical cancer cells and its mechanism. Methods qPCR was used to detect the expression of H19 in cervical cancer tissues and different cervical cancer cell lines. The relationship between H19 and clinicopathological parameters in clinical patients with cervical cancer was analyzed. Immunoprecipitation assay was used to detect the interaction between H19 and Bcl2. Scrap healing test was used to detect the changes of migration ability of cervical cancer cells after H19, Transwell invasion assay was used to detect the changes of invasive behavior of cervical cancer cells after H19. Western blotting was used to detect the regulation of Ecadherin and Bcl2 protein by lncRNA H19. Results Compared with normal cervical tissues, the expression of H19 in cervical cancer tissues was higher than that in other cervical cancer cells. The expression of H19 was the highest in HeLa cells compared with other cervical cancer cell lines. Immunoprecipitation experiments confirmed that H19 could regulate the expression of Bcl2. Inhibition of H19 expression could inhibit the proliferation of cervical cancer cells and invasive ability. The expression of H19 was related to the pathological stage of cervical cancer and the lymph node metastasis.The higher the expression of H19, the higher the expression of H19 in cervical cancer tissues, and the higher expression of H19 in patients with lymph node metastasis.Conclusion H19 can regulate the expression of Bcl2 and affect the biological behavior of cervical cancer cells.