【Abstract】 Objective To investigate the effect of longchain noncoding RNA TUSC8 on the migration and invasion of cervical cancer and its mechanism. Methods qPCR was used to detect the expression and differences of TUSC8 and miR137 in cervical cancer tissues and normal cervical tissues. The correlation between TUSC8 and clinicopathological parameters in patients with cervical cancer was analyzed. Double luciferase reporter gene was used to detect the interaction between TUSC8 and miR137. The invasion of TUSC8 cells was detected by Transwell invasion assay. Scaffold healing test was used to detect the changes of migration behavior of TUSC8 after cervical cancer cells. Inhibitory effect of TUSC8 on the tumorigenesis of cervical cancer cells in nude mice by tumorigenesis. Results Compared with normal cervical tissues, the expression levels of TUSC8 and miR137 in cervical cancer tissues were upregulated. The difference was statistically significant. The expression of TUSC8 was related to the pathological stage of cervical cancer and lymph node metastasis. The higher the expression of TUSC8 in cervical cancer, the higher the expression of TUSC8 in patients with lymph node metastasis. Double luciferase assay confirmed that TUSC8 could bind to 3 'UTR of miR137 and could regulate the expression and activity of miR137. Inhibition of TUSC8 expression could inhibit the migration and invasion of cervical cancer cells. The posterior cervical cancer cell tumorigenic ability decreases after inhibition of TUSC8. Conclusion TUSC8 can regulate the expression of miR137 and affect the migration and invasion of cervical cancer cells.