【Abstract】 Objective To evaluate the clinical effects and adverse reactions of minimally invasive treatment of dental fluorosis. Methods 38 patients with dental fluorosis, 736 teeth, were divided into three groups according to the Smith classification: mild, moderate, and severe. The combination of enamel microabrasion, 10% carbamide peroxide athome bleaching, and penetrating resin technology were given to each patients. The effect of the treatment was evaluated by Vita shade guide matching. The teeth sensitivity was evaluated by Visual Analogue Scale, and questionnaires were used to survey the satisfaction of patients. Result There was a significant difference in SGU values before and after treatment of the three groups (P＜005). The VAS scores of all groups after home bleaching treatment were significantly different from those before treatment (P＜005). There was no significant difference of VAS scores between ‘1 week after treatment’ and ‘before treatment’ (P＞005). 100% of patients thought that the color of the teeth was "significantly improved" or "improved" by treatment. Conclusion The combination of enamel microabrasion, athome bleaching, and Resin Infiltration is a safe and effective method for minimally invasive treatment of dental fluorosis. It is in line with the principles of minimally invasive dental treatment and is worthy of further promotion and research.