Berberine is extracted from a Ranunculaceae Coptis,which is a isoquinoline alkaloid. In Coptis and its derivatives, the most widely used is the monomer of berberine,the most valuable active ingredients in Rhizoma Coptidis. In recent years, both at home and abroad published a large number of berberine and diabetes, cancer,Cardiovascular disease,hyperlipidemia,hypertension,inflammation, and other related literature.. Inflammations a group of protein complexes surrounded several proteins (eg:LRP3, NLRC4, AIM2 and NLRP6) the recognize of pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs).The disease according to the mechanical stress and release the damage signal induced secretion of potent proinflammatory cytokines cause the cell death. More and more animal model experments and other test system show that berberine has strong antiinflammatory, analgesic and antipyretic effect. This paper makes a review of recent progress in the regulation of berberine in inflammatory diseases.