Objective To investigate the effect of dobutamine assisted treatment on serum procalcitonin (PCT), brain natriuretic peptide (BNP), Ddimer (DD) and PCIS score in children with severe pneumonia. Methods 86 children with severe pneumonia in our hospital from October 2014 to October 2017 were selected and randomly divided into 2 groups. 43 cases in the conventional group were given routine treatment, while 43 cases in the study group were given dobutamine assisted treatment on the basis of routine treatment. The curative effect and the scores of PCT, BNP, DD and PCCIS before and after treatment were compared. Results After treatment, the levels of BNP, DD and PCT in the study group were significantly lower than those in the conventional group, and the differences were statistically significant (t=15.403, t=26867, t=7.681, P＜0.05). The PICS scores in the study group were significantly higher than those in the conventional group, and the differences were statistically significant (t=5.655, P＜0.05). PaO2 and SpO2 were significantly higher in the study group than in the conventional group, the differences were statistically significant (t=3.977, t=4.904, P＜0.05); the total effective rate of the study group was 97.7%, which was significantly higher than 72.1% of the conventional group, the difference was statistically significant (=10965, P＜0.05); There was no significant difference in the incidence of adverse reactions between the two groups (=0453, P＞0.05). Conclusion Dobutamine assisted treatment is an effective and safe way to improve the serum cytokines and PCT levels for severe pneumonia children with lower incidence of adverse reactions.