Objective To investigate effect of high flux dialysis on the effect of vivotoxin clearance and quality of life in patients with uremia. Methods In this study, 100 patients with uremia treated in our hospital from January 2015 to January 2017 were selected and randomly divided into observation group and control group. Patients in the observation group were given highflux dialysis, while those in the control group were given conventional hemodialysis. Toxin clearance, serum inflammatory factors, quality of life and skin pruritus scores were compared between the two groups. Results There were no significant difference in blood urea, serum potassium, serum creatinine and serum uric acid between the two groups after dialysis (P＞0.05). The levels of cystatin C, serum phosphorus, parathyroid hormone and β-2 microglobulin of the observation group were significantly lower than those of the control group (P＜0.05). Serum levels of CRP and IL-6 of the two groups were significantly decreased after dialysis, and the levels of the observation group were significantly lower than that of the control group (P＜0.05). In the SF-36 scale, items scores except for social function, somatic pain, and emotional functions in the observation group were significantly higher than those in the control group (P＜00.05). The degree of skin pruritus, the extent and the impact on sleep in the observation group were significantly lower than the control group, the difference was statistically significant (P＜0.05). Conclusion High flux dialysis has a better clearance effect on cysteine proteinase inhibitor C, parathyroid hormone and other large and medium molecular toxins, which can ameliorate the level of inflammation and itching symptoms, and improve the quality of life.