Objective To investigate the application of joint prosthesis replacement in the treatment of hip fracture and its influence on fracture healing and limb pain. Methods 96 patients from June 2015 to October 2016,with hip fracture were selected and randomly divided into the experimental group and the control group, with 48 cases in each group. The experimental group was treated with joint prosthesis replacement, while the control group was treated with dynamic hip screw fixation. All patients were given routine postoperative care. The bone metabolism and bone molecule cytokine content in serum before and after treatment pain, media content, joint function before and after treatment (Harris score and LKSS score) score and postoperative complications were observed.Results The patients underwent surgery for one month. The serum levels of PINP and PICP in the serum of the two groups were significantly higher than those in the control group (26.43 ± 3.54 vs VS (1256 ± 1.43), (19.45 ± 2.32) VS (10.12 ± (29.31 ± 3.67). The content of TRAP5b and GatK was significantly lower than that of the control group ［(17.62±2.11)VS(29.21±3.67),(953 ± 1.11) VS (22.32 ± 2.82)］. The difference was statistically significant (P＜0.05). The serum levels of BMP, TGFβ, FGF, IGFI and IGFII in the serum of the experimental group were significantly higher than those in the control group ［(9.32 ± 1.12) VS (4.39 ± 0.71), 36.64 ± 4.75 (16.36 ± 0.62), (11.32 ± 1.52) VS (5.13 ± 0.65), (8.66 ± 0.98) VS (4.14 ± 0.62) and (14.32 ± 1.79) VS (7.89 ± 0.92)］. The difference was statistically significant respectively(P＜0.05). After 3 months and 6 months,compared with the control group, the scores of Harris and LKSS in the two groups were significantly higher than those in the control group［(68.53 ± 11.61) VS (56.02 ± 12.51), (80.01 ± 3.82) VS (74.32 ± 4.41); (87.14 ± 12.72) VS (78.53 ± 10.43), (94.27 ± 4.79) VS (84.11 ± 3.22)］,the difference was statistically significant (P＜0.05); the incidence of postoperative complications in patients in the experimental group (10.42%) than in control group (2708%). The difference was statistically significant (P＜0.05).Conclusion The use of joint prosthesis replacement in the treatment of hip fractures can significantly improve the patient's hip and knee function, promote fracture healing and significantly reduce the pain of patients and postoperative complications.