Objective To investigate the clinical characteristics, maternal and fetal outcomes of premature rupture of membranes (PROM), and to analyze the influencing factors and provide theoretical basis for prevention of PROM. Methods 200 women with PROM and 200 normal pregnant women hospitalized in our hospital from November 2015 to November 2017 were enrolled and divided into observation group and control group. The clinical characteristics of PROM were observed, and the mode of delivery and fetal outcome were recorded. The maternal education, infection and age of the two groups were investigated, and the risk factors of PROM were analyzed by single factor and multiple factors. Results The main clinical manifestations of PROM were sudden vaginal discharge, meconium mixed or vernix caseosa. Among 200 PROM, there were 125 cases of cesarean section, 45 cases of vaginal delivery, 18 cases of breech extraction, and 12 cases of forceps delivery; Among 202 new born, There were 27 cases of neonatal asphyxia, 56 cases of premature birth, 18 cases of neonatal pneumonia, 24 cases of intrauterine infection, 21 cases of fetal distress, and 9 cases of neonatal death in the observation group, which was significantly higher than those in the control group, the difference was statistically significant (P＜0.05); Infections, history of abortion, and abnormal fetal position between two groups were statistically significant (P＜0.05). Multivariate analysis showed that CRP≥10mg / L, abnormal fetal position, infection were the independent risk factors of PROM. Conclusion For PROM patients, cesarean section, breech extraction, forceps delivery are mostly chosen, and the incidence of neonatal complications is higher. CRP≥10mg / L, abnormal fetal position, and infection will increase the risks of PROM.