Objective To explore the relationship between bile acid metabolism and liver cirrhosis complicated with gallbladder stone. Methods 40 patients with liver cirrhosis complicated with gallbladder stone (the study group) and 36 cases of patients with simple gallbladder stone (the control group) admitted to our hospital from April 2015 to May 2017 were selected for the study. They were given the blood sampling at 1d before operation to detect the serum biochemical indexes ［total bilirubin (TBIL), direct bilirubin (DBIL), total cholesterol (TC), triglyceride (TG), total bile acid (TBA)］, and the liver tissue samples were obtained and the expression levels of farnesoid x receptor (FXR), bile salt export pump (BSEP) and multidrug resistance associated protein 2 (MRP2) in liver tissues were detected by immunohistochemical method, and the above indexes were given the correlation analysis. Results There was no significant difference in the TBIL level between the two groups (P＞0.05), and the levels of DBIL and TBA in the study group were higher than those in the control group while the levels of TC and TG were lower than those in the control group (P＜0.05). The levels of FXR, BSEP and MRP2 with ［(2.15±0.34), (4.21±0.51) and (4.35±0.56) points］ in the study group were lower than those in the control group (P＜0.05). Correlation analysis showed that the FXR, BSEP and MRP2 were negatively correlated with serum TBA and DBIL in patients with liver cirrhosis and gallbladder stone, and the expression level of FXR was positively correlated with BSEP and MRP2 (P＜0.05). Conclusion Bile acid metabolism abnormality is closely related to the liver cirrhosis complicated with gallbladder stone, and the downregulation of FXR, BSEP and MRP2 expression is its possible mechanism.