Objective To explore the effect of implant restoration in patients with chronic periodontitis, and the relationship with inflammation and oxidative stress. Methods 80 patients with dental defect and received implant restoration were grouped chronic periodontitis group and healthy control group, according to suffering from chronic periodontitis preoperative or not. 1, 3, 6, 12 months after implant restoration, the retention rate of 1 year was recorded. The root tips were detected to recorded the MBL, PD, mPLI and mSBI. ELISA method was used to detect the IL-1β, IL-6, MDA, SOD and GPx in gingival crevicular fluid. Results After implant restoration, the mPLI, mSBI, PD, MBL were all elevated with time (P＜0.01), which were higher in chronic periodontitis group than healthy control group (P＜0.01). After implant restoration, IL-1β, IL-6 and MDA were all elevated with time (P＜0.01), SOD and GP-x were all reduced (P＜0.01). After implant restoration, IL-1β, IL-6 and MDA all higher in chronic periodontitis group than healthy control group (P＜0.01), SOD and GP-x were all lower than healthy control group (P＜0.01). The retention rate of implants in each group was 100% in 1 year.Conclusion The clinical efficacy of implant restoration in patients with chronic periodontitis obviously in the short term. The phenomenon of marginal bone absorption was obvious, and there was inflammation and oxidative stress in the local microenvironment surrounding the implant.