【Abstract】 Objective To investigate the effect of sodium hyaluronate injection on the recovery of joint function and prognosis after the reconstruction of the anterior cruciate ligament of the knee joint. Methods 60 patients with anterior cruciate ligament reconstruction of the knee joint accepted by our hospital from March 2014 to March 2016 were selected and randomly divided into observation group (n=30) and control group (n=30) based on the random number table. Patients in the control group were treated with anterior cruciate ligament reconstruction surgery. On the basis of anterior cruciate ligament reconstruction surgery, patients in the observation group were given additional injection of sodium hyaluronate. The clinical effect, joint function recovery and prognosis of the two groups after treatments were analyzed. Results After treatment, the total effective rate of observation group and control group were 9666% and 80%, respectively. The efficacy of the observation group was significantly higher than that in the control group and the difference was statistically significant (P＜005). After treatment, the range of motion and the Lysholm score in the two groups were all significantly increased and the differences were statistically higher in patients of the observation group than that in control group (P＜005). The VAS score in observation group was lower than that in control group. The recovery of joint function was better than that in the control group. After treatment, the levels of osteocalcin, procollagen I carboxy terminal peptide and serum bone alkaline phosphatase were significantly higher than that in the control group. The levels of C reactive protein, white blood cells and fibrinogen in the observation group were significantly lower than that in the control group, there was statistical significance (P＜005). There were no obvious adverse reactions in the two groups after treatment. Conclusions Sodium hyaluronate injection applied to the reconstruction of anterior cruciate ligament of knee joint can reduce postoperative pain, promote joint function recovery, reduce postoperative adverse reactions, and has good clinical efficacy.