【Abstract】 Objective To grasp the time of occurrence of adverse reactions after vaccination and provide guidance for the possible abnormal reactions that may occur after vaccination. Methods All cases of vaccination data and clinical diagnosis of fever were collected through AEFI information immunization from 2014 to 2015 in Jinan and carried out statistical analysis. Results All the vaccines were given a fever response, with measles vaccine (9623%) and BCG fever (2727%). Based on the hypothesis testing of the occurrence curve of the febrile reaction of different vaccines, the distribution difference between the vaccines from inoculation to the occurrence of febrile reaction time was statistically significant (P＜ 005). A similar vaccine was used to classify and do the Breslow test, which further revealed that there was a statistically significant difference (χ2 = 112119, P＜001) between the bleach and polio vaccine and the other fever. Conclusion The incidence of fever adverse events was the highest after vaccination with measles vaccine, and the fever rate of BCG was the lowest，which can provide reference for timely and effective prevention of fever adverse reactions after vaccination.