【Abstract】 Objective To discuss the clinical efficacy of citalopram, vestibular rehabilitation training combined with cognitive behavioral therapy in the treatment of chronic subjective dizziness (CSD). Methods 142 patients with CSD treated in our hospital from April 2014 to March 2016 were selected and randomly divided into A, B and C three groups. Patients in group A were treated with citalopram, vestibular rehabilitation training combined with cognitive behavioral therapy, while patients in group B were treated with vestibular rehabilitation training and cognitive behavioral therapy, and patients in group C were treated with vestibular rehabilitation training alone. Changes of scores of Dizziness Handicap Inventory (DHI), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) in the three groups before treatment and after 2 weeks, 4 weeks and 8 weeks of treatment were observed and compared. Results The DHI scores (score of each individual item and total DHI score) of group A decreased significantly with the treatment process, and the decline was significantly greater than that in group B and that in group C. Before and after treatment, the HAMA score of group A decreased from (1987±401) to (798±399), and the HAMD score decreased from (2087±422) to (877±241). The HAMA score and HAMD score of group A were lower than those of group B and group C. There were no serious adverse reactions in the two groups during and after treatment. Conclusion The combined treatment with citalopram, vestibular rehabilitation training and cognitive behavior therapy is effective in the treatment of chronic subjective dizziness, with few adverse reactions.