【Abstract】 Objective To examine the clinical efficacy and security of esomeprazole in therapy of stroke complicating gastroesophageal reflux disease in the aged people. Methods Sixtyfour patients were randomly divided into treatment group (32 cases) and control group (32 cases). The patients in treatment group were orally administrated with esomeprazole 40 mg once a day. The people in the matched group were administrated with Omeprazole 20mg once a day. Clinical efficacy and the drug adverse reaction were compared between the two groups after treatment for 8 weeks.Results The symptoms of chest pain，acid reflux and heartburn in two groups were improved after treatment for 8 weeks. The efficient in treatment group (8438%) was higher than that in control group (7188%), (P＜0．05)．The incidences of adverse reaction of treatment group and control group were 94% and 63% ( P＞ 0. 05). Conclusion Esomeprazole is effective and safe in the treatment of stroke complicating gastroesophageal reflux disease in the aged people.