【Abstract】 Objective To investigate the effect of postoperative propofol sedation on rebleeding and clinical prognosis in patients with traumatic brain injury. Methods The clinical data of 131 patients with traumatic brain injury included in the February 2015 to January 2017 were collected and analyzed retrospectively. Results The levels of sedationagitation scale (SAS) and intracranial pressure (ICP) in the observation group were lower than those in the control group at 1 h, 2 h, 4 h and 8 h after operation, with statistical significance (P＜005). There were no significant differences in heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure(DBP) between the two groups at 1 h after operation (P＞ 005), but there was significant difference between the two groups at 2 h, 4 h and 8 h after operation (P＜005). The rate of rebleeding in the observation group(725%) was lower than that in the control group (1935%), with statistical significance (P＜005). The mortality rate in the observation group (870%) was lower than that in the control group (1452%), with no statistically significant (P＞005). The glasgow outcome scale (GOS) of the observation group was better than that of the control group at 6 months after operation, with statistical significance (P＜005). Conclusion Postoperative sedation in patients with traumatic brain injury can avoid severe restlessness, reduce the incidence of rebleeding, and improve longterm prognosis with better quality of life.