【Abstract】 Objective To investigate the clinical effects of the therapeutic effect of the treatment of cerebral apoplexy hemiplegia with the trinity therapeutic instrument. Methods From August 2013 to December 2016, 122 patients with stroke rehabilitation in our hospital were selected and equally divided into observation group and control group with 61 cases in each group, accorded to random number table method. The control group was given conventional rehabilitation methods. The observation group was given the trinity therapeutic instrument treatment based on the control group that were the main methods were acupuncture, neuromuscular electrical stimulation and massage therapy. Results The total effective rate of the observation group and the control group were 934 and 820%, respectively, and the total effective rate of the observation group was significantly higher than that of the control group (P＜005). After rehabilitation, the neural function defect score of observation group and control group were 567±241 points and 811±218 points that were significantly lower than those of before rehabilitation of 1214±246 points and 1211±314 points(P＜005). The observation group was significantly lower than the control group (P＜005). The exercise and walking function scores in the observation group and the control group after rehabilitation were significantly higher than those before rehabilitation (P＜005), while the observation group were also significantly higher than those in the control group (P＜005). Conclusion The application of the trinity therapeutic instrument in the rehabilitation treatment of stroke hemiplegia can promote the improvement of nerve function, promote the improvement of sports and walking function, and improve the prognosis.