【Abstract】 Objective To study the influence excent of edaravone for the oxygen free radical scavenging capacity and cerebral blood flow parameters of patients with craniocerebral injury operation.Methods 58 patients with craniocerebral injury operation in our hospital from September 2015 to November 2016 were randomly divided into control group (routine perioperative treatment group, 29 cases) and observation group (routine treatment and edaravone group, 29 cases)，then the oxygen free radical scavenging capacity indexes and cerebral blood flow parameters of two groups before and after the treatment were detected and compared.Results The oxygen free radical scavenging capacity indexes and cerebral blood flow parameters of two groups before the treatment were compared. The differences were not statistically significant (P＞005). The SOD levels of observation group at first and second week after the treatment were higher than the levels of control group. The MDA，LPO and·OH were lower than that of control group. Vmean，Vmin，Qmean and Qmin of observation group were higher than that of control group. The Zc and DR of observation group were lower than that of control group (P＜005).Conclusion The influence of edaravone for the oxygen free radical scavenging capacity and cerebral blood flow parameters of patients with craniocerebral injury operation are great，and it plays better clinical role for the repair of body injury and improvement of cerebral blood supply.