【Abstract】 Objective In order to provide foundation for prevention and treatment of ischemic stroke, the research for the relationship between the anxiety disorders existing patent with foramen ovale (PFO) and cerebral infarction was carried out.Methods 274 patients with PFO were divided into group one(56cases), group two(36 cases), group three(48 cases) and group four(104 cases). Group one had anxiety disorder and PFO. Group two had no anxiety disorder. Groups three had anxiety disorder but no PFO. Group four had no anxiety disorder and no PFO. Results There was no significant difference of incidence of cerebral infarction between group two and group three. There was difference of incidence of cerebral infarction between he other groups. Group one had high incidence of cerebral infarction, then followed group two and group three. Group four had a relative low incidence rate.Conclusion Anxiety disorder with PFO may increase the incidence rate of cerebral infarction.