【Abstract】 Objective To explore left ventricular (LV) energy loss in assessing the change of left ventricular hemodynamics quantitatively during diastole of maintenance hemodialysis patients（MHD）by Vector Flow Mapping(VFM). Methods Thirtytwo patients with MHD (hemodialysis group) were employed while matched with 31 healthy people (control group). The average total energy loss (ELT), basal level energy loss (ELB), papillary muscular level energy loss (ELM) and apical level energy loss (ELA) of LV , LV vortex area and LV circulation of isovolumetric diastolic phase(P1), rapid filling phase (P2), slow filling phase (P3), atrial systolic phase (P4) were obtained by a dedicated VFM workstation. The difference of energy parameters between the two groups was compared. Results aELT in P1, aELT, aELB, aELM, aELA in P2，aELA in P3 and aELT, aELM, aELA in P4 of hemodialysis group were higher than those of control group (P＜005 or P＜001). The vortex area in P1, circulation in P2 and P4 of hemodialysis group were higher than those of control group (P＜001 or P＜005). There was a positive correlation between aELT and E/e in P2 and P4（r=0402，P＜005；r=0732，P＜001）. Conclusion The energy loss of LV at different levels during diastole in maintenance hemodialysis patients has been increased, which suggests that a significant the left ventricular hemodynamics change occured abnormally during diastole, and VFM might be used to provide innovative quantitative indicators to evaluate the changes of the left ventricular diastolic function in maintenance hemodialysis patients precisely.