Objective Some studies have suggested that collagen type 3 alpha 1 (COL3A1) rs180025 is associated with pelvic organ prolapsed (POP). And some studies hold the opposite idea. The purpose of this study was to evaluate whether collagen type 3 alpha 1 is a risk factor for pelvic organ prolapse. Methods Relevant literature sources were searched using databases including Medline, Embase, China National Knowledge Infrastructure (CNKI), Wanfang until now. Search terms included ‘Pelvic Organ Prolapses’,‘Urogenital Prolapse’,‘Vaginal Vault Prolapses’ combined with ‘COL3A1’. There is no limit to the language and country in search of articles. But the selected articles are casecontrol studies. RevMan 5.0 were used for this metaanalysis. Results Five studies with a total of 1274 participants (701 cases and 573 controls) were included in the analysis. The results are as follows: Allele A vs G: OR=0.98, 95%CI 0671.43, P=0.92; Homozygous model AA vs GG OR=1.51, 95%CI 0.47-4.82, P=0.48; Heterozygous model GA vs GG:OR=0.89, 95%CI 0.69-.14, P=0.37; Dominant model GA+AA vs GG: OR=0.92, 95%CI 0.63-1.33, P=0.65; Recessive model AA vs GA+AA: OR=1.64, 95%CI 0.54-4.95, P=0.38.Conclusion According to consequence the mateanalysis, we could knew that there was no significant correlation between COL3A1 and the risk of POP. t The POP is related to the race.