Objective To evaluate the effect of dyclonine mucilage on stress reaction during extubation in patients with hypertension．Methods 80 patients undergoing general anesthesia were randomly divided into two groups, with 40 cases in each group. 2% lidocaine were sprayed to the throat and glottis of the patients 1min before the intubation in two groups. The control group was smeared with 2mL paraffin oil on the distal third of tracheal tube before intubation. The observation group was treated with dyclonine in the same position. The other anesthesia measures were equal in two groups. The SBP, DBP, HR and agitation score and tolerance for tube, pharyngalgia and hoarseness in both groups were observed before anesthesia (T0)，at 1min before intubation (T1), at intubation (T2), at 1 min, 3 min after intubation (T3, 4)，at 1 min before extubation (T5), at extubation (T6)，at1, 3, 5min after extubation (T7, 8, 9). Results There was no significant difference in SBP, DBP and HR between groups at T0-T4（P＞0.05）. The SBP, DBP and HR in observation group were lower than control group at T5-T8（P＜0.05）. The agitation score and tolerance for tube in observation group were lower than control group at T5-T8（P＜0.05）. There was no significant difference in pharyngalgia and hoarseness between the groups. Conclusion Dyclonine mucilage can effectively relieve the cardiovascular response during extubation and reduce the adverse reactions during recovery.