Objective To investigate therapeutic effect of percutaneous endoscopic lumbar discectomy on lumbar disc herniation. Methods From July 2014 to July 2015, 64 patients suffered from lumbar disc herniation and underwent percutaneous endoscopic lumbar discectomy under local anesthesia were retrospectively reviewed. There were 34 males and 30 females，with an average age of 50.2 years. The mean course of disease was 19.6 months. All patients had single level involved. The pain and daily activity was evaluated by the visual analog score(VAS), Japanese Orthopaedic Association（JOA）Scores and the Oswestry disability index (ODI), respectively. Modified MacNab criteria were employed to measure the clinical results.Results In the postoperative each groups, VAS of back and leg pain and ODI scores were significantly lower(P＜0.01) and JOA score observably higher than the preoperative (P＜0.01). At 12 months after operation based on the modified MacNab criteria, the results were excellent in 44 cases, good in 16 cases, fair in 4 cases. The excellent and good rate was 938%.Conclusion The near and medium term efficacy of PELD for lumbar disc herniation is positive with the recovery time and lumbar function and gradually improved.