Objective To study the effect of blood pressure changes on heart and brain ischemia in patients with acute cerebral infarction and coronary heart disease and find the range of blood pressure suitable for these patients.Methods 107 patients of acute cerebral infarction complicated with coronary heart disease were divided into hypertension group (n=59) and nonhypertension group (n=48). The patients were simultaneously monitored by ambulatory blood pressure and dynamic electrocardiogram. The blood pressure values and their corresponding ischemia events were studied. Blood pressure values are divided into five subgroups: A (~120/~80mmHg),B(120~140/80~90mmHg),C(140~160/90~100mmHg),D(160~180/100~110mmHg) and E (180~/110~mmHg). Ischemia events in four categories: heart ischemia, cerebral ischemia, heartcerebral ischemia and heartcerebral without ischemia. The distribution of different classification of cardiovascular and cerebrovascular events in each blood pressure subgroup were observed.Results Heartbrain without ischemic events of hypertension group were mainly distributed in SBP C,D group(=106.158,60.465,P＜0.01) and DBP B,C group(=79.196,55.099,P＜0.01). Heartbrain without ischemic events of nonhypertension group were mainly distributed in SBP B, C group=56.090,123.131,P＜0.01) and DBP B, C group(=124.196,74130,P＜001). Conclusion There is no heartbrain ischemia event in patients with acute cerebral infarction complicated with coronary heart disease. The appropriate range of blood pressure of hypertension group is 140~180/80~100mmHg. Nonhypertension group of appropriate blood pressure range is 120~160/80~100mmHg.