【Abstract】 Objective To explore the effect of clinical health education pathway in the treatment of patients with chronic kidney disease complicated with hypertension.Methods 407 patients with chronic kidney disease were randomly divided into observation group (n=200) and control group (n=207) according to the order of admission. In the control group, the traditional health education was carried out. The observation group carried out the clinical health education path. The knowledge of the diseaserelated knowledge, the medical treatment (such as the control of hypertension knowledge, regular medication, reasonable diet, Alcohol and appropriate exercise), the occurrence of complications, hospital experience and satisfaction and length of stay and hospital costs were analyzed.Results The hospitalization experience and satisfaction were 1000% in the observation group, which was higher than that in the control group (903%). The hospitalization cost of the observation group was less than that of the control group (P＜005).Conclusion The implementation of clinical health education pathways is conducive to improve the knowledge of hypertension in patients with chronic kidney disease and hypertension, improve the compliance behavior, and enhancing the ability of patients to manage their own diseases, shorten the hospital stay, reduce hospital costs, help to improve patient experience and satisfaction, delay the progress of CKD and improve the quality of life of patients.