【Abstract】To explore whether corilagin would suppress the proliferation of gastric cancer SGC7901 cells through mediation of NOTCH1/Hes1 pathway. Methods Three different concentrations (0μg/ml, 10μg/ml and 100μg/ml) of corilagin were obtained in our study. At different time points (0h, 24h and 48h), MTT assay was used to analyze the cell viabilities. QPCR was used to measure NOTCH1 and Hes1 mRNA expression. Western blot was performed to analyze the protein expression of NOTCH1 and Hes1.Results The cell viabilities of gastric cancer SGC7901 cells were concentrationdependently and timedependently supressed by corilagin. Then, the mRNA and protein expression of NOTCH1 and Hes1 were also concentrationdependently inhibited by corilagin in gastric cancer SGC7901 cells, after 48h of intervention. Conclusion Corilagin could suppress the proliferation of gastric cancer SGC7901 cells through downregulation of NOTCH1/Hes1 signal pathway.