【Abstract】Objective To assess the role of IL23R on bladder cancer by investigation of polymorphisms of the IL23R gene. Methods 226 Chinese Han patients with histologically proven bladder cancer were investigated with polymerase chain reactionrestriction fragment length polymorphism.Results In all three single nucleotide polymorphisms of IL23R studied, the distribution of genotype and allele frequencies of rs10889677 differed significantly between patients and controls. The frequency of allele C of rs10889677 was significantly increased in cases compared with controls (02898 vs.01833, odds ratio OR=1716, 95% confidence interval CI=10882762). Conclusion The result indicates that IL23R polymorphisms may play an important role in the susceptibility of bladder cancer.