【Abstract】 Objective To explore the diagnostic value of prenatal ultrasound in the diagnosis of fetal infection in pregnancy.Methods 890 pregnant women received prenatal intrauterine infection virology (TORCH) from October 2010 to October 2016 were selected. TORCHIgM was detected for all mothers and TORCHIgM was positive Pregnant women to give ultrasound diagnosis, compare test results and pregnancy outcome.Results Of 890 cases of prenatal routine TORCH examination of pregnant women, there were 272 cases with pathogen infection. The infection rate was 3056%. There were 172 cases with TORCHIgM positive. The positive rate was 6324% (172/272). The positive rate of TORCHIgM was higher than that of other pathogens (P<005). Of 172 cases of TORCHIgM positive mothers for prenatal ultrasound diagnosis, a total of 38 cases of uterine fetal development abnormalities, the incidence was 2209% (38/172).The positive rate of TORCH was 1147% (85/741),the positive rate of TORCH was 5839% (87/149) in 149 cases.The positive rate of TORCH was lower than that of pregnant women with normal pregnancy,the difference was statistically significant (P<005).Conclusion Prenatal ultrasonography can be used to diagnose abnormal fetal development in fetuses infected with pathogens during pregnancy. It is necessary to strengthen the understanding of pregnancy pathogen infection in pregnant women, pay attention to the characteristics of different pathogens to do prenatal examination, take effective measures in time, To ensure maternal and child safety.