【Abatract】 Objective To evaluate the value of high frequency color Doppler ultrasound in the differentiation of benign and malignant thyroid nodules．Methods 204 cases of thyroid nodules (n=285) confirmed by surgical pathology or FNAB were underwent color Doppler ultrasound．All nodules were evaluated from thyroid echo. The echo type of nodule，shape， border，A/T，the relationship with thyroid capsule，the type of calcification，acoustic halo，blood flow distribution and the metastatic condition of cervical lymph nodes．OR of every ultrasonic index was calculated．Results The ORs of thyroid echo, irregular shape, vague margin，A/T≥1, coated capsule, incomplete acoustic halo，microcalcification and metastatic cervical lymph nodes were all greater than 1．Conclusion The thyroid echo，irregular shape，vague margin，A/T≥1，coated capsule，incomplete acoustic halo，microcalcification and metastatic cervical lymph nodes are valuable on the differentiation of benign and malignant thyroid nodules．