【Abstract】 Objective To explore the clinical effect of CTguided percutaneous microwave ablation therapy (PMAT) for patients with lung cancer. Methods We analyzed the CTguided PMAT effects for 38 patients with 45 lesions from March 2013 to March 2016 in our hospital. Modified response evaluation criteria in solid tumors (RECIST) was evaluated treatment effects and the common terminology criteria for adverse events version 40 (CTCAE) was assessed to complications. Results After 6 months of treatment, 26 cases experienced complete response (CR) (26/45, 578%), and 9 cases experienced partial response (PR) (9/45, 200%) in all patients. The overall response rate was 778% (CR+PR), and the 1, 2, and 3survival rates after PMAT were 895% (34/38), 737% (28/38), 632% (24/38),respectively. Among all cases, 8 cases presented with symptoms of pneumothorax. There were 13 with fever, 5 with hemoptysis and 1 with auricular fibrillation. Conclusion CTguided PMAT is a welltolerated, safe and effective method for patients with lung cancer who they are inoperable or unwilling to accept surgical treatment.