【Abstract】 Objective To explore whether emodin could attenuate LPSinduced in ammation in RAW2647 cells, and its involved potential mechanism. Methods RAW2647 cells were divided into Control group, LPS group, Emodin group, LPS+Emodin group, LPS+Emodin+siRNAPPARγ and LPS+Emodin+siRNAscrambled group. The mRNA and protein expression of ICAM1, MCP1 and PPARγ were measured by qRCR and western blot. The level of TNFα was evaluated by ELISA. Then, the phosphorylation of NFκB p65 was also detected by western blot. Meanwhile, siRNAPPARγ transfection was performed to knockdown PPARγ expression in cells. Results After 6 hours LPS stimulation, LPSenhanced ICAM1, MCP1 and TNFα expression, LPSreduced PPARγ expression, and LPSpromoted NFκB p65 activation were substantially compromised by emdoin in RAW2647 cells. However, these effects of emodin was noticeably blocked by siRNAPPARγ in cells. Conclusion Our results indicate that LPSinduced in ammation is potently compromised by emodin very likely through the PPARγdependent inactivation of NFκB in RAW2647cells.